International And Comparative Human Resource Management Management Essay

International And Comparative Human Resource Management Management Essay This assignment includes journals which are in core with international human resource management (IHRM). In a modern competitive environment most of the organization move globally. IHRM is basically management of human resource internationally for the business occurs globally. Hence IHRM plays a vital role in globalized business. Compare to HRM, the IHRM have additional responsibility with regard to planning, staffing, performance management, training development, compensation and repatriation in international context. The main objective of writing this journal is to identify how HRM practice and managing the people in multinational context and as well as to identifying and analyzing the theories of this particular topic. It gives me wide knowledge about international human resource management. This reflects journal is about nine critical areas of IHRM which was discussed in our class and my observation, my personal viewpoints and theatrical understanding of each session of IHRM class. In order to present my view point better I refer magazine, books, online web and relate my class theatrical understanding with real world examples. I believe this journal will help me to recollect all what I learn from my class to understand and expand my knowledge. Introduction to IHRM In modern competitive environment company efficiency is greatly influenced by the best human recourses. The globalisation made possible for an organisation expands their business in multinational level. Human recourses management in domestic involves all management decision and practices that affect directly the people who are working in the organisation. The first class about international human resources management (IHRM) was conducted by our lecturer Mr. Chandana Kumara and he gave us brief description about our unit plan course outline, learning and assessment method of this subject. In this class we learnt introduction of IHRM in multinational prospective. Also we learnt difference between domestic and international HRM. Human resource manager in multinational company together with HR activities they engage such as helping suitable working environment for the expatriates to avoid regional disparities, reduce cultural risk and to settle down in their working place. We learnt procuring, allocating and effectively utilising human resources and HR activities in foreign locations and also we understood the importance of selecting employees in all three nations such as host country, parent country and third country. IHR manager in an international organisation need to understand the values of host country employees against the home country employees values. The HRM activity such as human resource planning, staffing, performance management, training and development, compensation and industrial relations is more complicated in multinational context. The human recourses manager for an organisation which has branches in overseas need to have a good understanding of cultural diversities and ability to manage diversifies human capital effectively. Managing human resource management internationally is not easy due to the fact that we need to consider the government regulation, policies, cultural background and strategies to be followed to run the enterprise in the host country. Major factor in international human resource management is first we need to understand and satisfy the government regulations of three country nation such as parent country nation (PCN), host country nation (HCN), and third country nation (TCN). The international HR manager has to effectively handle these kind challenges to be successful in the business. IHRM needs additional HR activities such as international taxation, International relocation and orientation, administration service for expatriates, host government relations and language translation services when an organisation moves globally (Dowling Welch, 2004, p.g.7). As a result HR manger should be able to identify and evaluate HR in broader perspective to treat all the employees equally and pay attention fairly when they consider for any compensation and promotion. HR manager need to satisfy all three nations when he evaluates the employee performance in multinational organisation. Moving the organization internationally it involves different types of employees with different personal life style. The risk exposure is also very high when comparing with the domestic HRM. External factors such as the growth of the host country government and state of economy also play a major role when the organization does a business globally. These factors HR manager need to be aware for the organization success and to achieve its target goals. I got good overview of IHRM and the importance to managing the people with different cultural values in international context. Globalization and rapid increase in technology gives more prominence for IHRM in an organisation. Cultural Differences Second class is all about cultural framework. This part is basically describes on cultural behaviour of the society impacts on an organisational performance. Hence HR manager for an international organisation need to have clear understanding about culture for the host nation and knowledge about different culture practice in different nation to run the organization efficiently and to avoid any misunderstandings among the employees. Here we study different culture of each country related to human resource management and expatriate cultural shock experiences when they work in different state. HR manager must know well about host country culture to reduce conflicts, cultural shock among co-workers and to achieve the business objective of the organisation. Expatriate to overcome from frustration the organisation needs to give introduction and train them. Measuring and assessment of cultural situation can be divided into two. They are emic and etic prospective. Emic refers how own nation look at their own culture and Etic is refers how outsiders views about their culture. IHR manager should have clear knowledge about both with regard to accepted customs and values of the nation as well as his understanding and his view about their values and customs. After the etic and emic perspective we learn about cultural dimension. There are lot of framework to identify cultural difference such as Hofstedes five dimension and trompernaars dimensions. For an example discussed about Hofstedes five dimensions which are individualistic vs. collectivism, power distance, uncertainty avoidance, masculinity vs. femininity, long term vs. short term and Confucianism. In order to explain the above dimension examples taken Sri Lanka and Maldives, Saudi Arabia and Japan for us to get an understanding about of these countries in terms of cultural dimension. The HR managers should have a clear understanding of the importance of host country culture. We learnt china, Japan, Sri Lanka, India which has high power distance because they give respect to the position as well when they address someone they call sir or madam. USA and UK have low power distance because they have friendly relationship between employer and employee. They all called by first name of the person. Uncertainty avoidance is high where a country can take high risk as well as planned before problem arises. Example we can say UK and USA prefer to take risk so they have high uncertainty avoidance countries. Sri Lanka is a low uncertainty avoidance country. Femininity refers to a country which gives priority to relationship. Example like Sri Lanka, India they give first priority to relationship. Masculinity is where a country gives priority for values, money, status and success.UK and USA are masculinity countries. Individualistic countries achieve their success individually. UK and USA are individualistic countries they identify their success individually. Collectivi sm is where countries achieve their success by set of group. Sri Lanka is a collectivism country. Managers in the multinational organisation, they need to work globally valuing the customs and practice of the locals of the country they work. IHR managers in the international organization need to understand and work in accordance to the cultural diversity of working people for the efficiency and to safe guard the interest of the stakeholders. The knowledge I gained in the class will help me in the future when I am working with different cultural people. The Organizational context This chapter explains how the organizations managed and controlled in international level and effectively handling its human recourses with different cultural values and languages. Also lecture explained span of control of smaller and lager organizations and the benefits of having centralized/ decentralized operation. Organization operated with centralized operation where the decision making with top level management. The manager need to mange internal factors to compete internationally. There are six factors which direct the organization effectively and efficiently. They are size, structure, host country demand, national culture and language, flow and volume of information, operation modes, control mechanism and geographical dispersion. We have to consider these six factors when moving and doing business internationally because this will impact on HR functions. IHRM plays a vital role in selecting and training people and the factors affecting HR with some of them are political and legal nature, technology, and the nature of the product. HRM has the responsibility to select the right people for the tight positions. Also it was discussed about the managers leadership style in the organization and their cultural values and their attitude. Mangers need to adopt different style according to the situation to improve the organization performance. There are some different types of leadership styles to regulate different kind of situation. They are participative, consultative, paternalistic and autocratic styles. Participate is basically always like to work, consultative consults its subordinates to go through specific objective, paternalistic is more concern about employees who works in its organization and autocratic is have a control on whats its operates. A control mechanism plays a major role in an organization. Control can be formal and informal. A formal control mechanism mainly includes for the firm of an organizational structure, reporting system, budget, performance target and formal communication. Informal coordinates its resources and activities not only in the domestic but also for the international level. Its basically includes personal relationship and informal communication and corporate culture. From this class lecture I have understood that the HR manager plays a vital role in an organization. Because they have to know about the different structure and changes which occurred during the external and internal environment. HRM in the host county context This topic explains about issues and problems relate to IHRM in the host country context. This chapter identifies and discusses drivers that interact between global standardization and localization of HRM practice when an organization operates with number of subsidiary operates worldwide. The organization has to decide whether to operate with standard HR policy need to be implement in all worldwide subsidiary or to be localized in accordance with country wise. The implementation of standard HR policies vary from parent country to host country according to culture, maturity, institutional environment, the mode of operation and subsidiary roll. When multinational enterprises (MNE) decide to standardize or localized its operation globally, it needs to have global mindset with local responsiveness. When implementing HR policies globally, the parent company needs to respect host country culture and traditions. There are four factors which have a major impact on standardization. They are host country environments or work place, mode of operation, size and maturity and subsidiary mandate. Need to adopt local institution requirements such as host country government policies and regulations and Host country employees education system and their expectations. Host country culture and workplace environment is different from the parent company culture. Hence localization would be suitable because the host country employees will be find it difficult in adapting to a different culture. Culture determines the standardization in the placement, processes and practices in the work place. For example if the host country belongs to high uncertainty avoidance the employees tend to be rather risk averse and prefer fixed compensation packages or seniority pay. Selection of mode of operation is essential in determining the standardization of work practices. When it is a fully owned subsidiary there is more possibility to standardize than in alliance. Standardization of the organization depends on size and maturity of the firm. Standardization is essential in order to build individuality in all the outlets of the organization. When the subsidiary plays a major part, the work practices and policies of the subsidiary would be standardized to add value. Th is subsidiary becomes relatively important. According to my opinion adapting to the host country background and culture is a critical factor rather than organizing a socializing program. HSBC, being a multinational company has the slogan of Worlds Local Bank, and also in Sri Lanka McDonalds quit beef burgers in India due to the culture problem raised in India and Pizza hut have been initiated to provide variety of rice and pizzas according to citizens taste and eating habits. The advantage for global standardize HR polices are ease of administration and better efficiency and effectiveness. HR policies will be much consistency and transparency. Standardization can be achieved thorough HR practice such as staffing procedure; staff appraisal system, staff training and development programs and corporate code of conduct. (E.g. Unilever, HSBC) Both Standardization and localization for MNE has advantages and disadvantages. Parent company need to adapt suitable HR policies in host country globally for the efficient and effective function. Sustaining International Business Operations This is the topic which identifies the introduction about staffing and the approaches of staffing. Staffing is very important for an organization and in human resource management staffing is a process for recruiting and selecting the best candidate from the pool of the candidate. The objective of this chapter explains about the approaches of staffing. An organization which is having subsidiary internally has different approaches. They are as follows: ethnocentric, polycentric, and geocentric and regiocentric. Each method includes pros and corns depending on the situation. Ethnocentric gives more importance to the parent company and it is having an authority against subsidiary operations. In this approach autonomy is limited and strategic decision is made by headquarters (Dowling Welch, 2004, P.58).this approach is managed by PCNs. This approach will retain a good communication, good coordination and strong control with parent company. Key position is hold by parent company and independent decision making is limited to the HCN and TCN. Polycentric explains MNE treats each subsidiary as separate national entity and gives autonomy to formulate decision to the subsidiary (Dowling Welch, 2004, P.59). This subsidiary is operates by local nationals. This staffing approach method is so effective and it gives more advantage to the host country nationals (HCNs). It eliminates the language barriers and adjusts the expatriate problems. Basically subsidiaries are managed by host country nation. For an e.g. HSBC is more rely on polycentric approach. Geocentric explains the MNE takes a global approach to its operations. It is accompanied by a worldwide integrated business and nationality is ignored in favor of ability (Dowling Welch, 2004, p.g.60) it gets the best people for the right job. Here subsidiaries are managed by PCN, HCN and TCN because to get the best work force in order to shine in operational and strategic level. Regiocentric explains that utilizes a wider pool of managers but in a limited way (Dowling Welch, 2004, p.g.62). Each individual HR person or organization has to take each approach regarding to its situation. We cant apply all the approach for a particular situation we must analysis and compare the situation and think what approach is more suitable for this kind of situation after that apply the staffing approach. Roles of expatriates to act as agent of direct control, to act as an agent of socialization, to coordinate the building of sustainable networks within the host country, to act as boundary spanners and to transfer competence and knowledge (Dowling Welch, 2004, p.69). International assignment includes different reasons such as to fill up the position, build up management and organization and the period of assignments can be short, medium and long term and non standard forms of assignments are commuter, rotational, contractual and virtual assignments. The functions of the expatriate: as an agent for direct control, as an agent, as network builder, as boundary spanners, and to coordinate the building of sustainable networks within the host country and transfer information and capability. Expatriate also undergo so many challenges. They are cultural issues, communicating difficulties, family absence and health problems. Here after I would say expatriate are more aware of their tasks it will lead to the success of the organization. Recruitment Selection for International Assignments Staffing Recruitment and selection are the important factor in human resource management. International recruitment and selection are important and difficult task when doing business globally. Recruiting is basically selecting a good candidate for a right job after recruit the selection process will continue in the process. That is basically gathering all information and selecting a best candidate. In this chapter mainly explains about expatriate recruitment and selection process as well as the success and failure of expatriate and the direct indirect cost of expatriates. The expatriates are used to transfer knowledge, control the organization as well as to fulfill the needs of the organization. The performance of the achievement will rank the organization. In this class mainly discuss about the recruitment and selection process done internationally for assignments. Here also discuss about major difference between the domestic and international staffing, firstly it says the firm have predisposition towards to hold the key position in headquarters and subsidiaries and by host government and the firms ability to attract the right candidate. To achieve the international assignment the expatriate should give their best shot to identify their personal trait. To prove that they should have a good leadership style, adoptability, flexibility, accept and adopts changes and work as calm and relaxed when under pressure times. Convince the managers to send the best employees for the international assignments are the main role for corporate HR. The four myths of global manager are there is a universal approach to management, people can acquire multicultural adaptability and behaviors, there are common characteristics shared by successful managers and there are no implements to mobility. Our lecturer spend some time in discussing the global manager and there function. The global manager job is tough to handle because most of the time they live abroad and they use to the different culture as well as they adapt to it. When the HR manager is recruiting employees for international assignment they have to motivate the staff to accept the foreign assignment so HR manger have to say that they are proving attractive salaries, financial incentives and other salary based benefit. When the organization is expanding their business globally they have to make sure staffing methods and policies are in line with host country laws. Selection also play major role in HR function. Expatriate failure is mainly premature return of expatriate. It will occur due to family concerns, early completion of assignments, cultural shock, security concern, lifestyle, poor performance, due to wrong selection and repatriate issues. For an example expatriate work in china they will come across cultural shock due to the poor performance. This will lead to the failure of expatriates. Analyzing the performance would be inability to adjust to foreign country, length of assignment, willingness to move, work related factors and psychological contract. Expatriate failure will cause direct cost and indirect cost. Direct cost includes airfares, associated relocation expenses and salary and training. Indirect cost will includes damaged relationship with host country and demotivating the local staff. To overcome this factors MNE should send knowledge person for the right assignment before sending the staff make sure to attend the pre departure program. International assignment will help the expatriate to gain knowledge in related topics and it will lead to achieve their career succession well. Training Development This chapter explains about one of the HRM function. Training and development plays a vital role for employees to achieve their target. In HRM recruiting selecting the first aspect and second is training development. Providing training in work place is to improve the current work, flexible in work as well as to adopt changes and challenges and work successfully in a given situation. Expatriate can perform well when they adopt and practice the training. To be last in the global market we need training as well more firms are focusing on the task of human resources as a significant part of their core competence and competitive advantage. Functions of Expatriate training contain many factors. They are Pre departure training, effective cultural training, host country business practices, host country labour laws, management styles, economic legal factors and relocation training and language training. The expatriates who work in abroad are not be aware of the host country function and cultures. To overcome this issue they have to undergo pre departure system which help the employees to know about the organisations, functions of the organisation and culture of the host country. Pre-departure training would include cultural awareness programs, preliminary visits, language training, practical assistance, training for the training role, TCN and HCN expatriate training. The success of the expatriate is depending on pre departure programs. It will give confidence to expatriate to do their work in host country. Effective cultural training also plays a major role because employees who selected to work abroad also find difficult to adopt host country culture. They undergo cultural shock so to overcome these better to have culture training. Trained expatriate will be more confident when they work in host country. Cultural training will provide confident to the expatriate to work effectively in host country. Cultural training and preliminary visit are important factor in pre departure program. Language training also plays an important role because an expatriate enter into a country and they use different language then expatriate will face difficulty. It will lead to a poor performance as well as communicate with other employees also lacking. Comfortable communication will lead to success and poor communication will lead to failure so to overcome this issue if they undergo language training it will help to be confident in host country. For an example if an employee going to China or France without attending language training they will face lot of problem. An effective employee will always go under language training before going to the host country. To compete successfully in the global market MNEs firms are focusing on the task of human resources as a significant part of their core competence and competitive advantage. To improve in competitive advantage training and development are important. Performance Management Performance management is a process which highlights in running the multinational organization and improves the entity, subsidiary unit and corporate performance as a whole to estimate whether they have achieved their target and pre determined goals. Introducing new methods to the labor force which will helps the multinational organization to carry out the employee performance to present level to the desired level. Through identifying the employees performances MNEs can evaluate the employees strengths, weaknesses and gaps between the desired one and actual one. During this process they can identify the employees in different levels. The organization proved training and development program for the employees to work easily at their home country. The major advantage of performance appraisal is selecting the right person for the right job. Because to reach the success. Mainly recruit the right employee as an expatriate to achieve the success in the global market. To motivate them the organization need to provide benefits and compensation to promote them and achieve the target goal of the organization. The organization should be very cautious when evaluating the subsidiaries sometimes it will get into demote situation. Because subsidiaries are different due to many other factors that affect performance appraisal such as who conducts the appraisal, use of standardized or customized appraisal forms, frequency of appraisal and performance feedback host country environment. There are three types of goal. They are hard goals, soft goals and contextual goals. Performance appraisals and these types of goals will help the firm to manage and control the work force and cultural to be flexible when dealing with people. Therefore performance appraisal system for subsidiary needs to be modified according to the environmental changes. The performance of the expatriate determined with support from headquarters host country culture, family consideration and external environment of the subsidiary it operates. Hence we could standardize and implement similar performance appraisal system in our entire subsidiary when evaluating performance appraisal for expatriate. Re entry and Career Issues This topic explains the challenges faced by expatriate when they enter into their home country. Re entry to their home country will lead to new challenges. Repatriate who are going to host country after finishing their task they have to return to their home country. When they come to their home country they will experience re entry shock. Expatriate will experience the cultural shock when they return back and experienced the difference of unusual things in home country. This will happens when the expatriate stayed for long time in the host country and use to the cultural differences. So when they come to home country they will experience the differences. In addition, after returning the expatriate may discover the organizations culture and subordinates also have change and expatriates feel working in a new environment. The re entry process includes four phases. They are preparation, physical relocation, transaction and readjustment. Preparation is basically when an expatriate return to theory home country they have to be well prepared. HR department must do the needful thing to the repatriate. The organization will provide the checklist when the expatriate return to their home country. Physical relocation means dismiss and finale the personal effects and breaking ties with same age group and friends and moving to the next positioning. Transaction refers to adjustment and settlement in the home country. When expatriate move to their home they need accommodation such as basic needs to fulfill the expectation. For an example such as basic needs housing, schooling, banking facility, transport facility, insurance, medical insurance and facility. Readjustment is includes in coping home country changes, reverse cultural shock and career demands. To overcome the re entry issues in home better to design a repatriate program. It will help the expatriate to avoid fear and adjustable to their home country culture. The expatriate can have Pre re entry program before they enters to their home country. This program is useful before entering into their home country. This will also help to adjust their selves in their home country. I firmly believes that HR manger have to play an important role in an expatriate re entry process. Conclusion International human resource management plays a major role in every organisation to provide a successful staff base and also achieve the firm target internationally. International human resource management mostly rely on HR issues and challenges. Throughout all the lectures I understand about the HR roles and challenges faced when expatriate enter into the host country as well as issues occur when expatriate re enter to their home country. After understanding about the international human resource management I realize HR manger plays a vital role in recruiting, selecting, training an employee for the right job globally. The success of the multinational organisation depends on HR managers selection. HR manager have a responsibility to make sure to improve skills and knowledge of the employees in order to shine in domestic environment as well as global environment. These reflective journals help me out to understand about human resource management globally. Our lecturer Mr. Chandana kumara discusses lot of questions and argues with students in related topic. It helps me gather more information in related topics in international human resource management.

Telecommunications Law

Telecom Law and Regulation Professor: David Olson September 14, 2012 Week 2 Case Study What is the natural monopoly ? Natural Monopoly is a monopoly that exists because the cost of producing the product (i. e. , a good or a service) is lower due to economies of scale if there is just a single producer than if there are several competing producers. (http://www. linfo. org/natural_monopoly. html) Today, telecommunications technology affects lives to a greater degree than ever before.Communication has evolved over many years from the earliest attempts at verbal communication to the use of sophisticated technology to enhance the ability to communicate effectively with others. A natural monopoly is said to exist in an market where the costs of production are such that it is less expensive for demand to be bet by one firm than it would be for that same demand to be met by more than one firm (Benjamin et al. , 2005).Every time a telephone call is made, a television is watched, or a personal computer is used, benefits of telecommunication technologies are being received. The American television industry is presently undergoing rapid change. Where once there was a limit on viewing options imposed by scarcity of electro-magnetic spectrum, confining most views to handful of channels that were dominated by three COM distribution systems, cable television is emerging now as â€Å" the television of abundance,† (Sloan Commission, New York 1981).A natural monopoly is said to exist in any market where the costs of production are such that it is less expensive for demand to be met by one firm than it would be for that same demand to be met by more than one firm (Benjamin et al. , 2005). Examples of natural monopolies are railway systems and telephones systems. All the phones should be connected and network together to attain the highest benefit. The monopoly is called natural because many competitors in these markets tend to die out leaving just one or a few providers fo r any given geographic area.But, the essence of the concept of a natural monopoly is there, that these are markets that end to have one or few providers. I believe that the government should treat telephones, cable and/or broadcasting companies has a natural monopoly. The technology industry has been a major problem in areas of the United States. Before wireless transmission really ever became a reality, cable was the ruler. After reading and viewing information about this topic customers live in around of the U. S.A that have limited cable service providers in their area and there is only one Cable Company to choose from which proves a natural monopoly. It has been verified time and time again about the lack of competition, the patrons are the ones who pay more for cable services. More over, the absences of superiority programming that the providers were not motivated to provide better service to consumers. The Commission is not the only regulatory authority showing interest in cab le television over the years. Local government has also been quite active in the regulation of local cable providers.Indeed, local governments for a long time insisted that cable providers apply to them for permission to be a local â€Å"cable franchisee† and local governments would often extract costly concessions from cable providers in exchange for granting those franchise rights (Benjamin et al. , 2005) The notion of having competition may end up costing more doesn't prove to be true in most cases, in general having the opportunity to choose the best providers with what is needed on service is far better than having dismal programming and choices.It is in the preferences and providers having all the choices for the consumers that are of benefit and one that is a win-win. Competition does not necessarily prove the notion that it costs more for hardware and software, that these are designed to be able to provide maximum number of customers. The concept of telecommunications may be defined as the transmission of information from one location to another by electronic means. Telecommunications is using electronic systems to communicate. Life is constantly changing and has been shifting faster since the rapid advancements in telecommunication.For the reason that ongoing attempts to find improved and supplementary efficient ways to communicate, the process of communication has gradually enhanced and I believe it will continue to do so. References: The Linux Information Project (2005). Natural Monopoly Definition. Retrieved 9/11/2012 from http:// (http://www. linfo. org/natural_monopoly. html) Benjamin, Douglas Gary Lichtman, Howard Shelanski, and Philip J. Weiser, (2006). Telecommunications Law and Policy Sloan Commission, (1981). On the Cable: The Television of Abundance

Physical And Treatment Of Cancer - 1556 Words

Physical Settings To date MSK has twenty-four facilities throughout New York and New Jersey providing a multitude of inpatient and outpatient services associated with the study, diagnosis and treatment of various forms of cancer. The Memorial hospital accommodates 471 beds, a 72,000-square-foot surgical center and state-of-the-art outpatient treatment center (Memorial Sloan Kettering Cancer Center, 2015c). MSK houses more than 35 core facilities with research being conducted in over 120 laboratories. Core facilities are dedicated to the development of scientific technology that aids in the study and treatment of cancer. Additionally Gerstner Sloan Kettering Graduate School of Biomedical Sciences and Weill Cornell Graduate School of†¦show more content†¦In addition, patients may receive treatment for rare blood disorders. Level of Clinical Activity Throughout 2014 nearly 147,000 patients were seen at MSK facilities. Of those more than 22,000 had an inpatient stay and over 593,000 individuals had outpatient visits (Memorial Sloan Kettering Cancer Center, 2015c). Clinical activities include patient treatment, clinical trials, research studies and educational training. MSK currently operates one of the world’s largest clinical research programs. During 2012 MSK physicians conducted in excess of 1,100 clinical studies related to both pediatric and adult cancers (para. 14). The Department of Psychiatry and Behavioral Sciences makes psychological care available to patients and their families as part of MSK’s committee to clinical care; however, the number of patients that partake in these services has not been quantified. In collaboration with affiliated universities, MSK has more than 1,600 residents and clinical fellows and nearly 600 research associates (para. 17). Organizational Structure What is now known as the Memorial Sloan-Kettering Cancer Center originally started with a single hospital in New York during the late 1800’s which eventually came to be known as the Memorial Hospital for the Treatment of Cancer and Allied Diseases (Memorial Sloan Kettering Cancer Center, 2015c). During the

The Human Of Bone Marrow Transplantation - 1632 Words

â€Å"It should be noted that marrow grafting could not have reached clinical application without animal research, first in inbred rodents and then in outbred species† E. Donnall Thomas, The Nobel Prizes, 1990 Animal research, as mentioned by Dr. E. Donnall Thomas in 1990 during his Nobel Prize award, has been crucial for the understanding of bone marrow transplantation (BMT) as a clinical therapy 138. His studies extensively used both mice and dogs as animal models. Other important models used in BMT research are rats, cats, pigs and non-human primates. The mouse is an excellent animal model because of the similarities in physiological and pathological traits that they share with other animals and humans. The field of BMT research has taken full advantage of these qualities, and mice have become one of the most commonly used BMT animal models. Transplantation (organ and hematopoietic) began in the early 20th century1. Several studies published between 1949-1953 139-141 documented that organs removed and immediately transplanted back into the same individual (autotransplants) were not rejected. However, organs from genetically different animals but from the same species (allografts) would eventually fail several days after transplantation. After the identification of the antigens that comprise the major histocompatibility complexes (MHC) in the 1960’s, transplantation between genetically different individuals became feasible 1. In the veterinary medical field, it wasShow MoreRelatedEssay on Bone Marrow Transplants1155 Words   |  5 PagesIn the last 40 years, the emergence of bone marrow transplants as a therapeutic modality for fatal disease and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life (G). Over 4,500 hematopoietic stem cell [ bone marrow] transplants performed on patients in the United States annually (H). Bone marrow transplants originally developed to allow the use of very high doses of cytotoxic drug treatments for malignancies, such as leukemiaRead MoreStem Cell Therapy Essay1036 Words   |  5 Pagesstem cell, it becomes a new hope in modern treatment. The first successful case of stem cell therapy in human was reported in 1959. Bone marrow restorations were observed in leukemia patients who received total body irradiation subsequent by intravenous injection of their twins’ bone marrow (Thomas et al, 1957). Nevertheless, that effect was transient and the following bone marrow transplantation attempts in non-twin patients and donors can eventually lead to patient’s death from graft-versus-hostRead MoreStem Cell Research Summary Article1058 Words   |  5 Pagesfunction is to make any other cell in the body. These cells are made from ones found in early human embryos, which are called blastocysts. ii. Embryonic stem cells are used to study how blastocysts grow in adults and how they affect other cells. iii. Embryonic cells start as a mass of cells and then grow and develop. This, in humans and other mammals is the start of an embryo that later forms the fully grown human after the many embryonic stem cells duplicate and differentiate. b. Adult stem cells (a.kRead MoreStem Cell Research913 Words   |  4 Pagesshown the ability to differentiate into different cell types, regenerate, and play a role in immune regulation. Studies with bone derived stem cells that I came across where focused on assessing the safety, limitations, and therapeutic effects of bone derived stem cells in patients with varying diseases. Out of the many studies being conducted with stem cell transplantation and disease, the studies being investigating the potential use of stem cells for diabetes caught my attention. The CDC NationalRead MoreThe Advantages and Disadvantages of Stem Cell Research Essay1197 Words   |  5 Pagescells are new, and more active in treatment. Firstly, adult stem cells can be removed from their bone marrow or their nervous system via peripheral system (sensory nervous cells, and motor nervous cells). An advantage that adult stem cells have is that fact that their bone marrow has a very rich supply of stem cells. The adult bone marrow is a soft, sponge-like material found in the core of bones which contain immature cells known as hematopoietic or blood-forming stem cells (National Cancer InstituteRead MoreInsulin-producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes553 Words   |  3 Pages2006). Thus, ÃŽ ²-cell replacement therapy in the form of transplantation would be a great path to prevent the complications. â€Å"Î’-cell is defined as a cell with the phenotype of a mature insulin-producing cell found in pancreatic islets†(Bonner-Weir et al., 2006, p.411). Nevertheless, the supply of insulin-producing cells is insufficient thus limits the extension of this therapy. It is said that ins ulin-producing cells can be used for transplantation therefore much attention is focused on finding its newRead MoreStem Cells And Regenerative Medicine : Cord Blood Banking And Its Therapeutic Application1636 Words   |  7 Pagesrepair â€Å" kit. This paper will conclude importance of stem cells in medicine because of their potential to regenerate and repair damaged tissue . Keywords : stem cells , umbilical cord stem cells , regenerative medicines , cell repair , s Stem cells . Human embryonic stem cells . Patient-specific therapy. METHOD : Articles for this review were selected from Pubmed Central and Medline databases and proquest databases. Introduction : Stem cells are able to generate mature terminally differentiatedRead MoreThe Stem Cell Therapy ( Iusct )1641 Words   |  7 PagesIntrauterine stem cell therapy (IUSCT) refers to treatment of a variety of fetal genetic disorders thought transplantation of either allogenic or genetically modified autologous stem cells. Stem cells become incorporated into the recipient tissue to start proliferation and differentiation through their pluripotent or multipotent potential to compensate for the missing or defective protein. This could be useful in treating fetal genetic disorders which are considered to be perinatally lethal or associatedRead MoreOrgan Donation And The Ethical Implications1441 Words   |  6 PagesORGAN DONATION The beginning steps of organ donations arose with an array of experimental transplants. Although it wasn’t until 1878 that the first successful transplant was completed, which used a bone from a cadaver. (14) From then on bone marrow transplants began by giving patients bone marrow orally to cure leukemia. This had no effect, but later when they used intravenous injections to treat aplastic anemia, there was some noticeable effects. Eventually developments began to arise that largelyRead MoreStem Cell Research872 Words   |  3 Pagesfrom the University of Wisconsin reported the first successful formation of human embryonic stem cells derived from early embryonic cells. This research was the first to demonstrate that it was possible for human stem cells to be manipulated and differentiated. Since the authorization in 2001 by President Bush to grant federal funding for research of stem cell lines, there has been a medical breakthrough in the use of human stem cells. Stem cells are now being examined in how they can help prevent